Running a PANEL seperately from your DNS

Hi,

I've got 2x PDNS DNS servers doing DNS.

I'd like to do a web panel on an additional VPS where I intend to host my sites, for wordpress / email / whatever else config.

Would it be possible to still do this and keep the DNS separate or can these types of panels configure DNS remotely?

How is it usually done? DNS + Panel on one box or can one separate them?

Thanks!